In the 1990s, phentermine was combined with other weight loss drugs. This drug combination was commonly called fen-phen. After reports of significant heart problems in users, the FDA pulled the other two drugs used in the treatment — fenfluramine, and dexfenfluramine — from the market (2Trusted Source). Buy Phentermine online without prescription
Phentermine goes by the brand names Adipex-P, Lomaira, and Suprenza, or you can find it in combination medications for weight loss, such as Qsymia. It’s a controlled substance due to its chemical similarities to the stimulant amphetamine — making it available only with a prescription. Your doctor may prescribe phentermine if you’re obese, meaning that your body mass index (BMI) is greater than or equal to 30. It may also be prescribed if you’re overweight with a BMI greater than or equal to 27 and have at least one weight-related condition, such as high blood pressure, high cholesterol, or type 2 diabetes (3Trusted Source, 4Trusted Source, 5Trusted Source).
While eating a well-balanced, reduced-calorie diet and exercising regularly are the cornerstones of weight loss, certain drugs can serve as powerful adjuncts.
One such drug is phentermine — one of the most popular weight loss drugs in the world.
It has been proven effective for short-term weight loss when used alongside a reduced-calorie diet and exercise.
However, using phentermine for weight loss is not without risks and side effects.
This article explains everything you need to know about phentermine, including its benefits, dosage, and possible side effects.
Use of Phentermine
Phentermine belongs to a class of drugs called “anorectics,” also known as appetite suppressants.
Taking phentermine helps suppress your appetite, thereby limiting how many calories you eat. Over time, this can lead to weight loss.
While the exact mechanisms behind the appetite-reducing effects of phentermine remain unclear, the drug is thought to act by increasing neurotransmitter levels in your brain (6Trusted Source, 7Trusted Source).
Neurotransmitters are your body’s chemical messengers and include norepinephrine, serotonin, and dopamine.
When your levels of these three chemicals increase, your feeling of hunger decreases.
However, you may build a tolerance to the appetite-suppressing effects of phentermine within a few weeks. In that case, you should not increase your dose of the drug but stop using it altogether.
Phentermine is thought to decrease your appetite by increasing neurotransmitter levels in your brain.
Effective for Weight Loss
Several clinical studies have proven that phentermine can boost fat loss.
The expected average weight loss with phentermine use is 5% of your initial body weight. Yet, over 12 weeks, it can be as high as 10%. This equates to a weight loss of 10–20 pounds (4.5–9 kg) for a 200 pound (90.7 kg) person (8Trusted Source).
In a meta-analysis of six studies, people who took the average dose of 27.5 mg of phentermine for 13 weeks lost an average of 13.9 pounds (6.3 kg) compared to 6.2 pounds (2.8 kg) in placebo groups (9Trusted Source).
While phentermine has been shown to be effective for weight loss, it may work better when combined with topiramate (10Trusted Source). Topiramate is a drug that has been used on its own to treat seizures but — like phentermine — also has appetite-reducing properties.
Topiramate and phentermine is a combination medication sold under the brand name Qsymia.
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